An integrative toxicogenomic analysis of plastic additives

In developed countries, contact with plastics is constant. Plastics contain a vast number of additives such as plasticisers, stabilisers, antioxidants, flame retardants, etc., that can impact human health. Most them have been studied separately; however, an integrative approach to identify genes, biological processes, molecular functions, and diseases linked exposure these compounds has not addressed until now. The genes most commonly affected by plastic are related apoptosis, cell death, proliferation differentiation, immunity insulin-related mainly associated cancer, mental disorders, diabetes mellitus type II obesity. functions included steroid hormone receptor activity implicated in immune signalling gonadotropin-releasing hormones. These processes the world, which endocrine system, diabetes, infertility strong interconnection among top 50 modulated shows pathways strongly interrelated. Therefore, studying effects through single-compound cannot be sufficient holistic more appropriate for evaluating potential